| Date | Home | Away | Result |
|---|---|---|---|
| 22/02/25 19:30 | Inter Miami CF | New York City FC | --- |
| 22/02/25 21:30 | Los Angeles FC | Minnesota United FC | --- |
| 23/02/25 00:30 | Orlando City | Philadelphia Union | --- |
| 23/02/25 00:30 | D.C. United | Toronto FC | --- |
| 23/02/25 00:30 | Columbus Crew | Chicago Fire | --- |
| 23/02/25 00:30 | Cincinnati FC | New York Red Bulls | --- |
| 23/02/25 00:30 | Atlanta United FC | CF Montreal | --- |
| 23/02/25 01:30 | St. Louis City SC | Colorado Rapids | --- |
| 23/02/25 01:30 | Nashville SC | New England Revolution | --- |
| 23/02/25 01:30 | Houston Dynamo | FC Dallas | --- |
| 23/02/25 01:30 | Austin FC | Sporting Kansas City | --- |
| 23/02/25 03:30 | Seattle Sounders | Charlotte FC | --- |
| 23/02/25 03:30 | San Jose Earthquakes | Real Salt Lake | --- |
| 23/02/25 21:00 | Portland Timbers | Vancouver Whitecaps | --- |
| 24/02/25 00:00 | Los Angeles Galaxy | San Diego FC | --- |