| Date | Home | Away | Result |
|---|---|---|---|
| 29/03/25 18:30 | New England Revolution | New York Red Bulls | --- |
| 29/03/25 18:30 | Toronto FC | Vancouver Whitecaps | --- |
| 29/03/25 20:30 | Colorado Rapids | Charlotte FC | --- |
| 29/03/25 23:30 | Atlanta United FC | New York City FC | --- |
| 29/03/25 23:30 | D.C. United | Columbus Crew | --- |
| 29/03/25 23:30 | Inter Miami CF | Philadelphia Union | --- |
| 30/03/25 00:30 | FC Dallas | Sporting Kansas City | --- |
| 30/03/25 00:30 | Chicago Fire | CF Montreal | --- |
| 30/03/25 00:30 | Minnesota United FC | Real Salt Lake | --- |
| 30/03/25 00:30 | Nashville SC | Cincinnati FC | --- |
| 30/03/25 03:30 | San Jose Earthquakes | Seattle Sounders | --- |
| 30/03/25 03:30 | Los Angeles Galaxy | Orlando City | --- |
| 30/03/25 03:30 | San Diego FC | Los Angeles FC | --- |
| 30/03/25 19:15 | St. Louis City SC | Austin FC | --- |
| 31/03/25 00:00 | Portland Timbers | Houston Dynamo | --- |